At The Good Care Group we care for a number of individuals living with Parkinson’s and understand how it can affect daily living and quality of life for those living with the condition, which affects 127,000 people in the UK.
A new type of gene therapy devised by Professor Nicholas Mazarakis, head of Gene Therapy at the Division of Brain Sciences at London’s Imperial College, has revealed results of its first human tests in The Lancet.
The therapy, designed to treat Parkinson’s disease, delivers 3 genes into the area of the brain responsible for controlling movement, the striatum, using a modified virus which is closely related to HIV. The idea is that the genes will boost the body’s production of the chemical dopamine, in which Parkinson’s sufferers are deficient. The therapy hopes to offer a long-term solution which will stimulate ongoing dopamine production in a different group of cells.
The treatment was first tested on rats and then primates, with surprising results, enabling movement in monkeys that had been disabled before treatment commenced. 15 trial participants were selected for the tests – 12 from France and 3 from the UK – all with advanced Parkinson’s disease. The results show that participant’s scores on movement assessment tests increased by an average of 30%, with results sustained over a 4 year follow up. Scans over this period revealed that participant’s brains were continuing to produce dopamine.
More extensive trials will take place once the delivery method and dose has been optimised by researchers.
Research recently carried out in Leicester indicates that folic acid could be beneficial in the treatment of Parkinson’s disease. The research has received coverage on ITV and has also been published in the journal Nature.
Scientists at the MRC Centre for Developmental and Biomedical Genetics (CDBG) and the Sheffield Institute of Translational Neuroscience (SITraN) at the University of Sheffield have discovered a new protein which could be key in the fight against Parkinson’s.
A group of Irish and Italian people with Parkinson’s disease gave an Irish dance performance at a health conference in County Clare – three years after an Italian neurologist set up a study group to examine the effect of Irish set dancing on Parkinson’s patients.